Acute rejection is the most common type of rejection after transplantation. It is mainly cellular immunoreaction, which occurs within 6 days to 6 months after kidney transplantation, and the most frequently occurs in one week to two months after transplantation.
Clinical manifestations: fever, lack of urine, discomfort, joint pain, weight gain, elevated blood pressure, creatinine and urea nitrogen.
At present, because of the use of powerful immunosuppressive drugs such as cyclosporine A, mycophenolate mofetil and FK506, the clinical manifestations of acute rejection are no longer typical, so it is necessary to closely observe the condition of the disease. Joint pain should be timely reported to the doctor, in order to get timely diagnosis, timely treatment.
The causes of acute rejection were mainly due to the improper dose adjustment of immunosuppressants (CellCellulose, cyclosporine FK506), the insufficient dose of immunosuppressants caused by diarrhea, the reduction of immunosuppressant dosage, virus (herpes zoster) and bacterial infection.
The number of acute rejection has an important effect on graft survival, so special attention should be paid to prevent the occurrence of acute rejection.
In order to prevent acute rejection, patients with high risk of renal transplantation and patients with poor matching (multiple recipients with moderate sensitization of HLA and recipients with poor HLA) were treated with sulfinil and zenepine before operation.
Take immunosuppressive drugs on time, do not arbitrarily reduce the dosage, to prevent randomness. The replacement of immunosuppressive drugs should be conducted under the guidance of the doctor, do not change casually. Patients with viruses, bacterial infections, diarrhea, Vomiting and other information should be promptly contact the transplant doctor in order to timely use of treatment and remedial measures. Regular detection of renal function and immunosuppressive drug concentration.
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