Infection is one of the complications of nephrotic syndrome, which may be related to protein loss, malnutrition, immune dysfunction and glucocorticoid therapy. Severe infection can be life-threatening, and it is also one of the reasons of why nephrotic syndrome is easy to relapse or poor curative effect. However, why nephrotic syndrome is prone to complicate infection?
1. Thrombosis, embolism, due to nephrotic syndrome can cause blood concentration, blood lipids, which means that the blood viscosity, the other due to the need for compensatory synthesis of albumin in the liver, body coagulation, anticoagulant fibrinolytic system will have inconsistencies; the body fibrinolytic disorders occur on the basis of blood viscosity, which means nephrotic syndrome is more prone to embolism, such as pulmonary embolism, cerebral infarction, coronary thrombosis, venous thrombosis and so on.
2. Acute renal insufficiency, nephrotic syndrome due to lack of effective hypovolemia caused by decreased renal blood flow, can induce prerenal azotemia, after treatment can be relieved, but for example, like minimal change nephrosis may cause acute renal damage, such as oliguria, anuria and so on. It may be related to the compression of renal tubules by high interstitial edema or the blockage of tubules by a large number of tubular proteins, resulting in high pressure in renal tubules, sudden decrease of glomerular filtration rate, injury and necrosis of renal tubular epithelial cells.
3. Metabolic disorders, due to a large number of protein loss from the urine, long-term hypoproteinemia, can cause growth and development of children. First of all, malnutrition, immunoglobulin can lead to reduced immunity, loss of metal-binding protein can lead to lack of trace elements, endocrine hormone binding protein deficiency can cause endocrine disorders; blood in hypercoagulable state can also promote glomerular sclerosis, tubulointerstitial lesions and promote chronic renal disease progression.
When an organ has problems with functions, it usually involves all organs and organs of the body. As a result, the human body is a whole. Therefore, it is necessary to consider the generality of the body. The occurrence of any one of the complications can be serious. If life-threatening complications are to be threatened, immediate diagnosis and treatment are needed.
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