Serum creatinine test results generally appear on the high side or low side, then what are the causes of high or low serum creatinine?What is the main reason I believe we all want to understand this problem, today we recommend this article, hope to help everyone.
High cause: serum creatinine concentration is mainly determined by glomerular filtration capacity (glomerular filtration rate). The decline in filtration capacity results in elevated creatinine levels. Most of the normal values of serum creatinine mean kidney damage, and serum creatinine can accurately reflect the damage of renal parenchyma, and is not a sensitive indicator. Because the glomerular filtration rate dropped to normal 1/3, serum creatinine increased significantly. That is to say, because human kidney compensatory ability, when kidney damage is light when the general discomfort is not obvious, so a lot of people when the real nausea, vomiting and dizziness, actually has kidney damage, the serum creatinine also began to rise significantly.
Low reason: nephropathy in patients with clinical examination will occur in the fluctuations of creatinine, manifested as higher than normal serum creatinine, and urine creatinine below normal. High serum creatinine is due to kidney in infringed by various causes, the first is the occurrence of impaired renal cell phenotype, the formation of pathological changes in kidney, stimulation of fibroblasts into myofibroblasts, and stimulate normal renal tissue invasion and inherent, occurred the same lesions, thus forming a kidney from the point to the surface, from local to the whole, expand the spread of excitation, thus entered the organic injury period (i.e. renal injury period), this time due to kidney damage caused by continuous, its excretion function decreased, causing toxins such as creatinine accumulation in the body, which appeared in the blood creatinine and urea nitrogen increase in urine creatinine decreased, renal filtration rate decreased. At the same time, the patient will also have high blood pressure, high edema and other bodies.
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