Principles of treatment of chronic nephritis

Principles of treatment of chronic nephritis

Bed rest: acute nephritis bed rest is very important. Bed can increase renal blood flow, can improve the urine abnormalities. Prevent and reduce complications, to prevent re-infection. When the edema subsided, blood pressure decreased, abnormal urine, can be used for moderate walking, gradually increase the mild activity, to prevent a sudden increase in the amount of activity.

Diet and Moisture: The amount of water intake to urine, edema, high blood pressure and the presence of heart failure to measure, in the acute phase to limit the water is appropriate, but not too much to prevent blood volume suddenly inadequate. Salt intake in the obvious edema and high blood pressure, to limit the 2g / d or so is appropriate. Protein intake, blood urea nitrogen below 14.28mmol / L (40mg / dl), the protein may not limit: 14.28 ~ 21.42mmol / L (40 ~ 60mg / dl) can be limited to daily per kilogram of body weight 1.0g; 21.42mmol / L (60mg / dl) or more, the daily weight per kilogram of 0.5g, protein to high quality protein is better, such as eggs, dairy, lean meat and so on. But generally advocate into the low-protein, high-sugar diet continued to diuretic start, until the basic relief of symptoms, to restore the regular diet.

Anti-infection treatment: nephritis in the case of acute infection in the case of infection to give enough anti-infection treatment, no infection, the general to not properly. The use of antibiotics to prevent the recurrence of the disease often ineffective.

Edema treatment: mild edema without treatment, salt and rest can disappear. Significant edema, can be used in furosemide, hydrochlorothiazide, spironolactone or diltiazem combined application, the general discontinuous application is better than continuous application.

Hypertension and heart failure treatment: the presence of hypertension in patients with conventional treatment of hypertension. Blood pressure was significantly increased, should not make blood pressure plummeted, or even down to normal, to prevent a sudden reduction in renal blood flow, affecting or aggravate renal insufficiency. Heart failure treatment, acute nephritis due to the early high blood volume problems, the application of digitalis effect is not necessarily ideal, the treatment should focus on the removal of water, sodium retention slide, reduce blood volume.

Anticoagulation therapy: According to the pathogenesis, glomerular coagulation is an important pathological changes, mainly for cellulosic deposition and platelet aggregation. Therefore, in the treatment, can be used anticoagulant therapy, will help relieve nephritis. Specific methods: heparin by 0.8 ~ 1.0mg / kg body weight by adding 5% glucose solution 250ml, intravenous infusion, once a day, 10 to 14 times for a course of treatment, interval 3 to 5 days and then the next course of treatment, a total of 2 to 3 A course of treatment. Dipyridamole 50 ~ 100mg 3 times a day. Salvia 20 to 30 grams of intravenous infusion can also be used urokinase 2 to 6 million u 5% glucose solution 250ml intravenous infusion, day 1, 10 days for a course of treatment, according to the condition of 2 to 3 courses. But should pay attention to heparin and urokinase can not be applied at the same time.

Antioxidants Application: Application of superoxide dismutase (SOD), selenium glutathione peroxidase and vitamin E. ① superoxide dismutase can make O- into H2O2, ② selenium glutathione peroxidase (SeGsHPx), so that H2O2 reduced to H2O. ③ Vitamin E is the body of plasma and erythrocyte on the fat-soluble scavenger, vitamin E and coenzyme Q10 can scavenge free radicals, blocking the free radical triggering lipid peroxidation of the chain reaction to protect the kidney cells, reduce the process of renal inflammation.

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